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Table 1: Summary for the Laboratory Professional
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The page below is a sample from the LabCE course
Pharmacology of Antihyperlipidemic Medications for Laboratory Professionals
. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.
Learn more about Pharmacology of Antihyperlipidemic Medications for Laboratory Professionals (online CE course)
Table 1: Summary for the Laboratory Professional
Drug Class
Example Drug
Primary Use
Laboratory Implications
Statins
Atovastatin
Dramatic reduction of LDL
Anti-inflammatory properties
Often first line treatment
ALT increase of 0.5-3.0%, especially in patients with pre-existing liver disease
Benign increase in CK
Rhabdomyolysis (rare)
Bile Acid Resins
Cholestyramine
Moderate reduction of LDL
Small increase in HDL
Vitamin K and folate abnormalities possible
Cholesterol Absorption Inhibitors
Ezetimibe
Usually combined with a statin in patients needing further decrease in LDL than a statin alone provides
Generally, well tolerated
Increased risk of liver toxicity in patients taking statin simultaneously
Niacin
Niacin
Popular over-the-counter medication to lower LDL and triglycerides while increasing HDL
Possible increase in serum liver enzymes, glucose, and uric acid
Fibrates
Gemfibrozil
Treats hypertriglyceridemia
Often used as an add-on to other lipid-lowering medications
Serum creatinine monitoring needed for those with renal disease
Decreased WBC count and HCT (rare)
PCSK9 Inhibitors
Evolocumab
Used in combination with a statin in patients needing a further decrease in LDL than a statin alone can provide
No muscle or liver injury noted
Generally, well tolerated
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