Table 1: Summary for the Laboratory Professional - LabCE.com, Laboratory Continuing Education

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The page below is a sample from the LabCE course Pharmacology of Antihyperlipidemic Medications for Laboratory Professionals. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Table 1: Summary for the Laboratory Professional

Drug Class	Example Drug	Primary Use	Laboratory Implications
Statins	Atovastatin	Dramatic reduction of LDL Anti-inflammatory properties Often first line treatment	ALT increase of 0.5-3.0%, especially in patients with pre-existing liver disease Benign increase in CK Rhabdomyolysis (rare)
Bile Acid Resins	Cholestyramine	Moderate reduction of LDL Small increase in HDL	Vitamin K and folate abnormalities possible
Cholesterol Absorption Inhibitors	Ezetimibe	Usually combined with a statin in patients needing further decrease in LDL than a statin alone provides	Generally, well tolerated Increased risk of liver toxicity in patients taking statin simultaneously
Niacin	Niacin	Popular over-the-counter medication to lower LDL and triglycerides while increasing HDL	Possible increase in serum liver enzymes, glucose, and uric acid
Fibrates	Gemfibrozil	Treats hypertriglyceridemia Often used as an add-on to other lipid-lowering medications	Serum creatinine monitoring needed for those with renal disease Decreased WBC count and HCT (rare)
PCSK9 Inhibitors	Evolocumab	Used in combination with a statin in patients needing a further decrease in LDL than a statin alone can provide	No muscle or liver injury noted Generally, well tolerated