Drug example: Niacin
Mechanism of action: Niacin reduces VLDL and LDL production in the liver as well as decreases the enzymatic breakdown of fat in fat tissues, causing a decrease in plasma triglyceride levels. It also decreases the breakdown of HDL, leading to increased serum HDL levels.
Use: A popular over-the-counter medication used to lower LDL and triglycerides while increasing HDL.
Drug toxicity: Niacin is believed to cause a release of inflammatory mediators, leading to the most common side effect of flushing. Taking aspirin before niacin can reduce the flushing.
It is also possible to see elevations in liver enzymes, serum glucose, and serum uric acid in patients using niacin.
