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Direct Thrombin Inhibitors
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Direct Thrombin Inhibitors
Examples:
This class includes drugs such as
dabigatran
.
Mechanism of action:
These drugs directly bind to and inhibit factor IIa (thrombin), resulting in a stoppage of the coagulation cascade.
Use:
These drugs are primarily used for patients with HIT who need a drug similar to the rapid onset of
heparin
.
Laboratory measurement:
aPTT, as with
heparin
.
Toxicity:
Excessive bleeding is possible. There is now a reversal agent for this class of drugs-
idarucizumab
. Idarucizumab is an antibody that binds to and neutralizes the drugs of this class.
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