Pathophysiology of MDS-IB2

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Pathophysiology of MDS-IB2

MDS-IB is broken down into two groups based on the number of blasts in the bone marrow and peripheral blood:
CriteriaMDS-IB1MDS-IB2
Bone marrow aspirate blast count (count >500 cells) 5–9% 10–19%
Peripheral smear blast count (count >200 cells) 2–4% 5–19%
Auer Rodsabsent might be present
Our patient falls into the MDS-IB2 category. Over half of all MDS-IB patients show cytogenetic abnormalities. The most common include del(5q), -7, del(7q) (our patient), +8, and del(20q). Slightly less than 50% do not have cytogenetic changes but rather various point mutations. Also, cytogenetic abnormalities and point mutations can be found in the same patient.