Dysplastic Megakaryocytic Cell Line (Dysmegakaryopoiesis)

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The page below is a sample from the LabCE course Myelodysplastic Neoplasms (MDS). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Dysplastic Megakaryocytic Cell Line (Dysmegakaryopoiesis)

Normal megakaryocytes measure approximately 20–90 µm in diameter and have a multilobed nucleus (refer to the image on the right).
Dysplastic megakaryocytes are:
  • Micromegakaryocytes: smaller than 20 µm
  • Hypolobated megakaryocytes: megakaryocytes with two attached lobes
  • Monolobated megakaryocytes: megakaryocytes with a single lobe
  • Megakaryocytes with separated nuclei: megakaryocytes with lobes completely separated

Normal megakaryocyte