Cytochemical Staining, continued

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The page below is a sample from the LabCE course Chronic Myeloid Leukemia (CML). Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Cytochemical Staining, continued

As shown in Table 2, LAP scores in a patient under normal circumstances would have a LAP score between 13 to 130. In a leukemoid reaction, scores greater than 160 would be expected. In cases of CML, the LAP score is low (less than 13) due to the fact that these cells are not being produced in response to an infection or stress but rather due to the neoplasm.
Table 2. Differentiating LAP score in Leukemoid Reaction versus CML.
ConditionLAP Score
Leukemoid Reaction>160
Normal, healthy person13 to 130
CML<13