CML in blast crisis may transform into acute leukemia, such as acute myeloid leukemia, acute lymphoid leukemia, or mixed phenotype leukemia.
Most patients with CML are diagnosed in CP. Patients in CP present with fatigue, weight loss, unexplained fever, night sweats, and left upper quadrant pain due to an enlarged spleen. A few patients are asymptomatic, and the neoplasm is discovered when routine blood counts are abnormal. Disease progression is accompanied by worsening symptoms, anemia, thrombocytopenia, and progressive splenomegaly.
