In CP, the leukemic cells infiltrate the bone marrow, peripheral blood, spleen, and liver. Approximately 50% of patients are asymptomatic at diagnosis, with CML being discovered during routine blood work that displays a significant leukocytosis and/or thrombocytosis and mild to moderate anemia. Splenomegaly is very common.
In BP, other tissues, such as lymph nodes, skin, bone, or the central nervous system, may be involved with the leukemic cells, a process known as extramedullary blast crisis (proliferation).
