Working with dry ice necessitates strict adherence to safety protocols and the use of appropriate personal protective equipment (PPE). Given its extremely low temperature, direct contact with dry ice can cause severe frostbite and tissue damage. Therefore, insulated, impermeable gloves, such as cryogenic gloves, should always be worn when handling dry ice. Gloves should be loose fitting in case they need to be removed if dry ice makes contact with the skin.
In addition to gloves, all general laboratory PPE should be worn, such as safety goggles or a face shield to protect against sublimation gases that can cause eye irritation or injury, lab coats, and closed-toe shoes.