Observe the differences in the cytoplasm between the two cell types. Both cells have blue cytoplasm; however, the monocyte (red arrow) has a grainy, gritty texture that is absent in the lymphocyte (blue arrow). In addition, fine red cytoplasmic granules in the monocyte are not apparent in the lymphocytes.
Notice the relatively regular nuclear shape of the lymphocytes versus the more complex nuclear shape of the larger monocyte. There is also a difference in chromatin texture between the two cell types. The lymphocyte chromatin is denser and clumped.
