Genotypic Assays

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The page below is a sample from the LabCE course Fundamentals of Molecular Diagnostics. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Genotypic Assays

Drug-resistance testing is also a form of genotypic assay. This testing looks for the genes of circulating RNA in the plasma of patients - to detect mutations that are known to confer specific drug resistance. Examples include:
  • NAAT testing of pure cultures of carbapenem-resistant bacteria, or clinical specimens (such as rectal swabs, and direct blood cultures). The tests detect defined carbapenem resistance genes.6
  • NAAT testing for the detection of resistant Mycobacterium tuberculosis (MTB). (Rifampin resistance gene rpoB is targeted.)7
6. Tenover FC. Using molecular diagnostics to develop therapeutic strategies for carbapenem-resistant gram-negative infections. FAront Cell Infect Microbiol. 2021;11:715821. Published 2021 Sep 28. doi:10.3389/fcimb.2021.715821
7. Centers for Disease Control and Prevention (CDC). Background on molecular drug-resistance (DR) tests. Last reviewed 2012. Accessed February 28, 2024. https://www.cdc.gov/tb/topic/laboratory/rapidmoleculartesting/background.htm