The Human Leukocyte Antigen (HLA) System (Online CE Course)

(based on 15 customer ratings)

Ethan Kentzel, MLS(ASCP)
Reviewers: Andrea Gordon, M.Ed., MT(ASCP)SH and Kevin F. Foley, PhD, DABCC, MT, SC

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This course covers the human leukocyte antigen system. The basic functionality of the immune system with emphasis on the role of the human leukocyte antigen (HLA) system is discussed along with the major histocompatibility complex which gives rise to HLAs. Principles and methodologies behind the various forms of HLA analysis are included. Also explored is the human leukocyte antigen's associative role in potential predisposition for disease, transplantation acceptance/rejection, graft-versus-host disease (GVHD), and alloreactivity.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s)
Approved through 9/30/2023
Florida Board of Clinical Laboratory Personnel Credit Hours - General (Serology/Immunology): 1.5 hour(s)
Approved through 9/1/2022

Objectives

  • Describe the basic functionality of the immune system with emphasis on the role of the human leukocyte antigen (HLA) system.
  • Explain the major histocompatibility complex which gives rise to HLAs.
  • Compare and contrast the molecular structures of HLA molecules and describe their interactions with cells of the immune and other bodily systems.
  • Detail the principles and methodologies behind the various forms of HLA analysis.
  • Discuss the human leukocyte antigen's associative role in potential predisposition for disease, transplantation acceptance/rejection, graft-versus-host disease (GVHD), and alloreactivity.

Customer Ratings

(based on 15 customer ratings)

Course Outline

Click on the links below to preview selected pages from this course.
  • Basics of the Immune System
    • History of the MHC in Humans and Other Animals
      • Discovery of the Major Histocompatibility Complex (MHC) and Human Leukocyte Antigens (HLA)
    • HLA 101 Terminology
      • HLA 101 Terminology
    • Immune System Overview
      • Overview of the Immune System
      • Overview of the Innate Immune System
      • The innate immune response is characterized by antibody production, cell-mediated apoptosis, and memory cell formation towards a specific response to ...
      • Which of the following cells are NOT part of the innate immune system?
      • Overview of Adaptive Immune System
      • Review of Cells in Adaptive Immune System: Pathways & Activation
      • Match the following cells of the adaptive immune response with its function.
    • HLA Nomenclature
      • Nomenclature of HLA Glycoproteins
      • Nomenclature of HLA Typings: Example
      • The first field of an HLA nomenclature is designated as the allele group or the antigenic level of the protein that is detectable serologically.
  • Genomic Distribution of the HLA System
    • Chromosome Location
      • MHC/HLA Location on Human Chromosomes
      • Which of the following is NOT a locus that is found in HLA class I?
      • There are four regions on band 21 of chromosome 6 that give rise to HLA genes.
    • Inheritance Patterns
  • Various Molecular Structures of the HLA System
      • Lymphocytes
      • Match the lymphocyte with its cluster of differentiation (CD).
    • Class I Structure and Functionality
    • Class II structure and Functionality
      • HLA Class II: Structure and Location
      • HLA Class II: Functionality
      • Class I and II Structure and Function Summary
    • Intro to HLA: mid-session review
      • Class I HLAs are expressed on all nucleated cells and present endogenous antigens to lymphocytes, while Class II HLAs are expressed on antigen present...
      • Which HLA glycoprotein is structurally characterized as a transmembrane protein with three heavy alpha chains and one light chain consisting of ß...
  • Methodologies of HLA Analysis
  • HLA's role in Transplantation, Alloreaction, and Disease Associations
      • HLA Functionality and ABO/Rh in Transplantation
      • Alloreactivity and Graft Versus Host Disease (GvHD)
      • HLA Alleles and Predisposition to Diseases and Drug Reactions
      • Match the types of rejection with the definition that meets the criteria for the type of reaction that would occur.
  • References
      • References

Additional Information

Level of instruction: Beginner to Intermediate
Intended Audience: Clinical laboratory technologists and technicians, and other health care personnel who have an interest in this subject matter. This course is also appropriate for clinical laboratory science students and pathology residents.
Author Information: Ethan Kentzel is completing his master's degree in Biomedicine and Business at Drexel University.  He holds a BS degree in Medical Technology from Slippery Rock University, and holds an ASCP MLS certification. Ethan has over half a decade of lab experience as a medical technologist working in various labs including Blood Bank, immunogenetics/HLA, Microbiology, and briefly as a generalist. While working as a laboratory scientist, he was also an adjunct professor for the Medical Lab Science program St. Christopher's Hospital for Children. Currently, he works as an educator and Program Director for the Medical Laboratory Science and Phlebotomy programs at Reading Hospital School of Health Science. He continues to teach at St. Christopher's Hospital for Children and at Reading Area Community College.
Reviewer information:
Andrea G. Gordon, M.Ed, MT(ASCP), SH has over 25 years of experience as a Program Director for various laboratory science programs. She has approximately 5 years experience as an administrator in higher education as a VP and Director of Education. Additionally, she has over 15 years of experience as a volunteer for NAACLS.
Kevin F. Foley, PhD, DABCC, MT, SC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina.

How to Subscribe
MLS & MLT Comprehensive CE Package
Includes 147 CE courses, most popular
$95Add to cart
Pick Your Courses
Up to 8 CE hours
$50Add to cart
Individual course$20Add to cart
Need multiple seats for your university or lab? Get a quote
Basic HLA inheritance


Chromosomal crossover during meiosis I (6).


DNA chromosomes of a human male (4).


Class II function (11).