Course Outline
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- Clostridioides difficile Infection
- Clostridioides difficile: The Bacterium
- Clostridioides difficile Strains and Toxins
- Emerging New Clostridioides difficile Strain: The 027 Strain
- Which of the following statements related to Clostridioides difficile is false?
- Pathogenic C diff strains can produce multiple toxins. Which statement is true regarding these toxins?
- True or False: A hypervirulent strain, commonly referred to as strain 027 is an aggressive strain of Clostridioides difficile that produces more toxin...
- CDI: Health Care Facts and Statistics
- CDI: Symptoms and Severity
- CDI: Symptoms and Severity
- CDI: Symptoms and Severity, continued
- CDI: Symptoms and Severity, continued
- Using white blood cell counts and creatinine levels may help clinicians classify the severity of CDI. If the white blood cell count is ≤15 ×...
- True or False: The risk of a recurrence of CDI is usually higher if the individual is older than 65 and taking other antibiotics while being treated f...
- True or False: Fulminant CDI is characterized by a severe infection associated with complications such as dehydration, hypotension or shock, kidney fa...
- CDI: Causes, Risk Factors, and Complications
- CDI: Causes, Risk Factors, and Complications
- CDI: Risk Factors for CDI
- CDI: Complications of CDI
- Which statement is true relative to the cause of CDI?
- True or False: Taking or having recently taken antibiotics is not considered a risk factor for CDI, but staying in a healthcare facility is considered...
- CDI: Treatment and Prevention
- CDI: Treatment
- CDI: Prevention
- Which statement is false relative to the treatment of CDI?
- Diagnosis of CDI: Laboratory Methods
- Diagnosis of CDI: Overview and Challenges
- Diagnosis of CDI: Overview and Challenges, continued
- Diagnosis of CDI: Laboratory Methods
- Diagnosis of CDI: Laboratory Methods, continued
- Diagnosis of CDI: Laboratory Methods, continued
- True or False: Laboratory-based tests to help diagnose CDI typically examine a serum or blood sample for certain toxins and/or specific enzyme antigen...
- True or False: One of the challenges in the diagnosis of CDI is stool specimens. C diff toxins are considered heat-labile and are only considered stab...
- Match the laboratory method with the method description.
- Laboratory Methods: Overview of Diagnostic Approach
- Laboratory Methods: Diagnostic Approach
- True or False: CDI should be suspected in a patient with acute diarrhea (≥3 loose stools in 24 hours) with no obvious explanation for diarrhea, ...
- Which statement is false when discussing the approach to diagnosing CDI?
- CDI: Commercially-Available Laboratory Tests
- Commercially Available Tests: Overview
- Commercially Available Tests: The Xpect® C Difficile Test
- The Xpect® C. Difficile Toxin A/B Test, continued
- The Xpect® C. Difficile Toxin A/B Test, continued
- True or False: Commercially available testing for CDI currently favors the employment of a rapid, technologically simple, and low-cost assay.
- Which of the following statements is false related to the Xpect® C difficile Toxin A/B test?
- Commercially Available Tests: The C. DIFF QUIK CHEK COMPLETE®
- The C. DIFF QUIK CHEK COMPLETE®, continued
- The C. DIFF QUIK CHEK COMPLETE®, continued
- The C. DIFF QUIK CHEK COMPLETE®, continued
- Which of the following statements related to the C. DIFF QUIK CHEK COMPLETE® test is false?
- A C. DIFF QUIK CHEK COMPLETE® test result showed vertical blue lines on both the "Ag line" and "Toxin line" with a vertical dotted blue line on t...
- Updated Guidelines and Recommendations
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: David J. Moffa, PhD, BCLD, has over 30 years of experience in the healthcare industry as an executive manager, clinical laboratory director, and medical laboratory scientist. He is currently a technical consultant for Kentmere Healthcare, Wilmington, DE, and until his retirement, was the Regional Director for LabCorp, Inc. He holds a PhD in medical biochemistry from the School of Medicine, West Virginia University.
Reviewer Information:
Lorna Ruskin, EdD, MLS(ASCP), is an Assistant Professor for the Medical Laboratory Science program at the University of Minnesota. Lorna has approximately 20 years of teaching experience in Medical Laboratory Science programs and has served as both the Program Director and Clinical Coordinator. She has done extensive research on laboratory simulation and has presented at national conferences regarding that topic.
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab by Vastian. His areas of expertise and professional passions include
clinical hematology and interprofessional education.
Course Description: This course is intended to provide a detailed description of the pathogenesis of the Clostridioides difficile infections, including details of the bacterium, health care statistics, symptoms, severity, risk factors, and complications. The course also discusses the various types of Clostridioides difficile infections and how the treatment and prevention strategies may vary based on the type of infection. Finally, the available laboratory tests used for identification are detailed.
