Course Outline
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- Introduction
- Nuclear Variations
- Hypersegmentation
- Conditions Associated with Hypersegmented Neutrophils
- Hypersegmented Neutrophil versus Normal Segmented Neutrophil
- Which of the following statements is true for hypersegmented neutrophils? (Choose all of the correct answers.)
- Hyposegmentation
- Conditions Associated with Hyposegmented Neutrophils
- Pelger-Huet Anomaly
- Normal Band Forms vs. Pelger-Huet Bands
- Bi-lobed Neutrophil
- Pelger-Huet Cells
- Single-Lobed Pelger-Huet Cells
- Which of the following are seen in Pelger-Huet anomaly?
- Barr Body
- Which of the following best describes a Barr body?
- Summary
- Cytoplasmic Variations
- Döhle Bodies
- Döhle Bodies, continued
- Toxic Granulation
- Toxic Granulation and Vacuolation
- Cytoplasmic Vacuolation
- Neutrophil with Normal Granulation
- Toxic granulation is seen most frequently in:
- Auer Rods
- Auer Rods, continued
- Which of the following inclusions may be seen in the cytoplasm of myeloblasts and promyelocytes?
- Auer rods are significant when they are seen in the cytoplasm of blast cells because they are diagnostic for:
- Chédiak-Higashi Syndrome
- Albinism and Chédiak-Higashi Syndrome
- Chédiak-Higashi Syndrome vs. Toxic Granulation
- Chediak-Higashi Syndrome Inclusions
- Chediak-Higashi Syndrome is characterized by which of the following?
- May-Hegglin Anomaly
- Alder-Reilly Anomaly
- Alder-Reilly Anomaly, continued
- Alder-Reilly anomaly inclusions may be found in which of the following white blood cell types?
- Which of the following inclusions has a similar appearance on a Wright's stained smear to a Döhle body?
- The inclusions that are frequently seen on the same peripheral blood smear with toxic granulation include: (Choose all that apply)
- What type of inclusions are present in the cell that is indicated by the arrow?
- The cell in this image is typical of other neutrophils on this peripheral blood smear from a patient with sepsis. Which morphologic term describes the...
- Summary
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory
technicians, laboratory supervisors, and laboratory managers. This course is
also appropriate for MLS and MLT students and pathology residents.
Course Description: This course covers morphologic variations observed in granulocytes, including nuclear and cytoplasmic variations.
Authors: by Marjorie A. Spahn, MLS(ASCP) and Barbara Minderman, MLS(ASCP).
Reviewer: Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
