Course Outline
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- White Blood Cell Disorders and Platelets
- Peripheral Smear Review Introduction
- Peripheral Blood Smear Preparation
- Evaluation Criteria: White Blood Cells and Platelets
- Criteria for Performing a Manual Review of the Smear
- Which of the images below represents an area of appropriate cell density to choose for performance of a manual differential?
- Platelet Estimates
- True or False: An automated platelet count of 40.0 X 109/L was reported. A review of the peripheral blood smear (see image to the right) reveals singl...
- Additional Comments
- Leukemoid Reaction and Toxic Changes
- Leukemoid Reaction
- Toxic Changes
- Thrombocytosis Associated with Toxic Granulation
- Case Study One
- The neutrophils illustrated in this image are representative of those seen in a female patient's peripheral blood smear. The total WBC was 28.5 X 109/...
- Toxic granulation noted in the neutrophils' cytoplasm reflects an increase in activity of which of the following? (Choose all that apply)
- A peripheral blood smear with many myeloid cells was presented for morphology review (see image on the right). Toxic granulation and vacuoles in the n...
- True or False: The association of increased platelets accompanying neutrophilia and toxic granulation, as illustrated in this image, is called thrombo...
- White Cell Nuclear and Cytoplasmic Abnormalities Related to Inherited Conditions
- Pelger-Huet Anomaly
- Chediak-Higashi Anomaly
- Alder Anomaly
- May-Hegglin Anomaly
- The inclusions noted in the cytoplasm of this white blood cell are most suggestive of which of these conditions?
- WBC inclusions: Summary
- Familial disorders: summary
- Case Study Two:The patient is a 10-year-old boy from Florida who developed abdominal pain while on a skiing trip with his family in Colorado. He was b...
- Case Study Two: Follow-up
- True or False: The cell indicated by the arrow in the image on the right is most consistent with Chediak-Higashi anomaly.
- Miscellaneous Granulocytic Cells
- Eosinophils
- Basophils
- A peripheral blood smear was reviewed and a representative field is shown on the right. Which of the following conditions may produce the results seen...
- Which of the following conditions is not associated with an increase in the white blood cell shown in the image on the right?
- Non Granulocytic White Blood Cells
- Platelets
- Giant Platelets
- Thrombocytopenia
- Pseudo-thrombocytopenia
- Thrombocytosis
- Platelet satellites (see image to the right) may account for low platelet counts as determined by automated hematology cell counters. Satellitosis is ...
- True or False: The image on the right is a microscopic field from a Wright-Giemsa-stained peripheral blood smear (1000X magnification). The structure ...
- A representative field from a peripheral blood smear on the right was held for morphological and clinical review as the total platelet count was 10.0 ...
- The peripheral blood smear shown in this image was held for review because of an increased platelet count. Conditions in which platelets are increased...
- This image is representative of a peripheral blood smear. As a result of this phenomenon, some automated hematology analyzers may report:
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory
technicians, laboratory supervisors, and laboratory managers. This course is
also appropriate for MLS and MLT students and pathology residents.
General Information: This program provides several outstanding interactive case studies, which cover pertinent topics in white cell and platelet disorders. Numerous excellent photomicrographs enhance the text, and interactive questions help the student master the material.
Authors:
C. William Reiquam, M.D. (1923-2015) was a clinical professor of pathology in the School of Medicine, University of Colorado. One of his areas of expertise was hematology.
Elmer W. Koneman M.D. is Professor Emeritus, Department of Pathology, University of Colorado School of Medicine. Residing in Breckenridge,CO, Dr. Koneman is a Board Certified Pathologist, former full Professor of Pathology University of Colorado School of Medicine. He is author of numerous journal articles and books.
Reviewer: Joshua J. Cannon, MS, MLS(ASCP)CMSHCM received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
