Tumor Markers (Online CE Course)

Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s) Approved through 11/30/2024

Florida Board of Clinical Laboratory Personnel Credit Hours - General (Clinical Chemistry/UA/Toxicology): 1.5 hour(s) Approved through 11/30/2024

Objectives

• Describe the features of a measurand that make for an ideal tumor marker.
• Delineate the factors that limit the utility of a component as a tumor marker.
• Correlate the presence of a tumor marker with its associated affected organ system.
• Differentiate between carbohydrate-rich tumor markers, protein-rich tumor markers, enzymatic tumor markers, and oncofetal antigens.
• List some of the emerging tumor markers for assessing breast cancer response to therapy and breast cancer risk.

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Course Outline

• Definitions and Background
• Key Definitions
• Cancer
• Tumor Marker
• Background
• Cancer Prevalence and Relative Risk
• Cancer Prevalence - New Cancer Cases by Site
• Cancer Predispositions
• Early Detection is Crucial
• Which statement would not fit the definition of a tumor marker?
• The Ideal Tumor Marker
• Specificity
• The Ideal Tumor Marker Would Have 100% Specificity
• Sensitivity
• The Ideal Tumor Marker Would Have 100% Sensitivity
• Concentration and Tumor Mass
• The Ideal Tumor Marker Would Be Indicative of Tumor Mass
• Analytical Aspects
• The Ideal Tumor Marker Would be Detectable in Blood or Biological Fluids
• The Ideal Tumor Marker Would be Adaptable to Laboratory Analysis
• True or False: Ideally, for a tumor marker to be considered as a screening tool, it should be consistently elevated at the early stages of the disease...
• Reference Values
• Reality
• Providing Diagnostic and Prognostic Support
• Examples of Tumor Markers
• Components
• Hormones
• Primary and Ectopic Hormones
• Example of Ectopic Production of Hormone from Lung Tumor
• Hormones as Tumor Markers
• Regarding hormone production, what is the term associated with producing a hormone at a distant site by non-endocrine tissue?
• Specific Proteins
• Specific Proteins as Tumor Markers
• Specific Proteins as Tumor Markers - Monoclonal Immunoglobulins
• Specific Proteins as Tumor Markers - Diagnostic Utility
• True or False: Detecting an immunoglobulin clone, such as IgM, is always associated with a malignant condition, such as multiple myeloma.
• Enzymes
• Enzymes as Tumor Markers
• Prostate-Specific Antigen (PSA): Background
• Prostate-Specific Antigen (PSA): Biochemistry and Genetics
• Prostate-Specific Antigen (PSA): Clinical Applications
• Prostate-Specific Antigen (PSA): Clinical Applications in Early Detection of Prostate Cancer
• Prostate-Specific Antigen (PSA): Clinical Applications in Prostate Cancer Screening (continued)
• Prostate-Specific Antigen (PSA): Clinical Applications in Prostate Cancer Staging
• Prostate-Specific Antigen (PSA): Clinical Applications of Monitoring Treatment
• Prostate-Specific Antigen (PSA): Clinical Applications in Monitoring Recurrence
• Prostate-Specific Antigen (PSA): Controversy
• The clinical utility of prostate-specific antigen (PSA) as a tumor marker includes which of the following?
• Carbohydrate Markers
• Carbohydrate Tumor Markers
• The Mucin-Rich Carbohydrate Tumor Markers
• CA 125
• CA 15-3
• CA 549
• CA 27.29
• Blood Group Antigen-Related Cancer Markers
• Blood Group Antigens as Tumor Markers
• CA 19-9
• Receptors
• Tumor Marker Receptors
• Estrogen and Progesterone Receptors
• Human Epidermal Growth Factor Receptor 2 (HER2/neu)
• Oncofetal Antigens
• The Oncofetal Antigens
• Alpha Fetoprotein (AFP)
• Carcinoembryonic Antigen (CEA)
• Mutations of Tumor Suppressor Genes
• Breast Cancer Susceptibility Proteins
• References
• References

Additional Information