Course Outline
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- Therapeutic Drug Monitoring
- Pharmacogenomics
- Personalized Medicine
- Polymorphism and Cytochrome P450
- CYP450 Enzymes
- CYP2D6 Enzyme
- Metabolizers
- Enzyme Abnormalities and Drugs
- Clinical Utility
- Warfarin Metabolism
- Warfarin Metabolism, continued
- If a person is classified as an ultrarapid metabolizer (UM), how much of a drug would they need?
- CYP450 Induction and Inhibition
- Table 5: CYP450 Inducers and Inhibitors
- A patient is taking cimetidine for a stomach ulcer. This drug inhibits CYP2D6. The patient is now prescribed amphetamine for narcolepsy. Amphetamine i...
- Genotype versus Phenotype
- Genotype versus Phenotype, continued
- Can Therapeutic Drug Monitoring Assess Pharmacogenetics?
- The Bottom Line
- The Bottom Line, continued
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical
laboratory technicians, laboratory supervisors and managers, as well as other health care personnel who are responsible for prescribing and administering therapeutic medications. This
course is also appropriate for MLS and MLT students and pathology residents.
Author Information: Kevin F. Foley, PhD, DABCC, MLS, SC, is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at the East Carolina School of Medicine in North Carolina. He received a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical laboratory scientist.
The author has no conflict of interest to disclose.
Reviewer Information:
Robert E. Moore, MLS(ASCP)CMSCCM, TC(NRCC) is the lead technologist in the toxicology laboratory at Kaiser Permanente in Portland, Oregon, where his responsibilities include methods development and validation, review of QC data, instrument troubleshooting, and employee training/competency assessment. In his career as a medical laboratory scientist, he has been a chemistry supervisor, toxicology supervisor, and laboratory director. He holds a Bachelor's degree in Biology from Marshall University.
Judi Bennett, BSM, MLS, is an Education Developer with MediaLab by Vastian, bringing over 30 years of experience as a medical laboratory scientist. Before joining MediaLab in 2010, she held key leadership roles, including Clinical Laboratory Manager, Microbiology Supervisor, and Senior Systems Analyst at Gwinnett Health System in Lawrenceville, Georgia. Her extensive knowledge of laboratory operations, combined with a strong commitment to healthcare quality and education, fuels her passion for developing engaging and effective learning tools for the next generation of laboratorians.
