Course Outline
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- Therapeutic Drug Monitoring
- Introduction
- Therapeutic Drug Monitoring Definition
- Pharmacogenomics Definition
- Basic Pharmacokinetics
- Drug Concentration Over Time
- Drug Metabolism
- Drug Elimination
- Half-Life
- Bioavailability
- Protein Binding
- Protein Availability and Drug Dosing
- Other Factors Affecting Drug Absorption and Distribution
- Given what you have learned thus far, which of the following statements below is true?
- Steady State
- Steady State Example
- Sampling
- Peak and Trough Sampling Times
- Why Therapeutic Drug Monitoring?
- Therapeutic Window
- Unexpected Concentrations
- Match each of the definitions shown below with the term from the drop-down box that it defines.
- A physician needs to prescribe a drug to a patient, but the drug has a narrow therapeutic window. The physician is concerned about possible toxic effe...
- Do All Drugs Benefit From Therapeutic Drug Monitoring?
- When is Therapeutic Drug Monitoring Not Useful?
- Alternatives to Therapeutic Drug Monitoring
- Examples of Drugs Monitored by Therapeutic Drug Monitoring
- Antibiotics
- Anticonvulsants
- Immunosuppressants
- Cardiac Medications
- Theophylline
- Albuterol is a fast-acting bronchodilator used acutely during asthma attacks. Which of the reasons below would best explain why TDM for albuterol is n...
- Laboratory Methods
- Chemiluminescence
- Pharmacogenomics
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical
laboratory technicians, laboratory supervisors and managers, as well as other health care personnel who are responsible for prescribing and administering therapeutic medications. This
course is also appropriate for MLS and MLT students and pathology residents.
Author Information: Kevin F. Foley, PhD, DABCC, MT, SC, is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at the East Carolina School of Medicine in North Carolina. He received a PhD in clinical pharmacology and toxicology from Brody School of Medicine, Greenville, NC. He has been working in laboratory medicine for over 15 years, starting his career as a medical technologist.
Reviewer Information:
Robert E. Moore, MLS(ASCP)CMSCCM, TC(NRCC) is the lead technologist in the toxicology laboratory at Kaiser Permanente in Portland, Oregon, where his responsibilities include methods development and validation, review of QC data, instrument troubleshooting, and employee training/competency assessment. In his career as a medical laboratory scientist, he has been a chemistry supervisor, toxicology supervisor, and laboratory director. He holds a Bachelor's degree in Biology from Marshall University.
Laurie Bjerklie, MA, MLS(ASCP)CM, is
currently an Education Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota and an M.A. in
Curriculum and Instruction from Saint Xavier University. She has over 15 years
of experience in higher education and has held program director and faculty
positions in both MLT and MLS programs.
