Course Outline
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- Myelodysplastic Neoplasms: Definition, Etiology, and Epidemiology
- An Update in Terminology
- Definition, Etiology, and Epidemiology
- Definition, Etiology, and Epidemiology, continued
- True or False: Myelodysplastic neoplasms (MDS) are caused by viral infections.
- True or False: Cytotoxic agents and chemical or radiation therapy may be etiologic factors of myelodysplastic neoplasms (MDS).
- Clinical and Diagnostic Features of MDS
- Clinical Features of MDS
- Clinical Features of MDS, continued
- Diagnostic Features of MDS
- Diagnostic Features of MDS, continued
- True or False: MDS is associated with microcytic, hypochromic anemia.
- True or False: The three myeloid cell lines in the bone marrow are granulocytic, erythroid, and megakaryocytic.
- True or False: Patients with MDS commonly have an enlarged liver and spleen.
- True or False: MDS is commonly associated with leukocytosis and neutrophilia in peripheral blood evaluations.
- True or False: Most patients with MDS demonstrate a vitamin B12 deficiency.
- The Morphological Features of MDS
- The Morphological Features of MDS
- Dysplastic Erythroid Cell Line (Dyserythropoiesis)
- Examples of Dysplastic Erythroid Cells (Dyserythropoiesis)
- Examples of Dysplastic Erythroid Cells (Dyserythropoiesis), continued
- Dysplastic Granulocytic Cell Line (Dysgranulopoiesis)
- Examples of Dysplastic Granulocytic Cell Line (Dysgranulopoiesis)
- Dysplastic Megakaryocytic Cell Line (Dysmegakaryopoiesis)
- Examples of Dysplastic Megakaryocytic Cell Line (Dysmegakaryopoiesis)
- True or False: In cases of MDS, the dysplasia of the erythroid cell line may include nuclear budding and ring sideroblasts.
- True or False: Normal megakaryocytes show multinucleation or monolobes.
- True or False: Granulocytic dysplasia in MDS may include nuclear hyposegmentaion and/or cytoplasmic hypogranulation.
- The Classification of MDS
- The WHO Classification of MDS
- True or False: The WHO classification of MDS groups MDS entities as those having defining genetic abnormalities and those that are morphologically def...
- True or False: MDS with increased blasts (MDS-IB) is defined as having >20% blasts in bone marrow or peripheral blood.
- The Prognostic Criteria of MDS
- Prognostic Criteria of MDS
- True or False: The IPSS-R identifies five prognostic factors based on blast percentage, cytogenetics, and cytopenias.
- The Differential Diagnosis of MDS
- Differential Diagnosis of MDS
- Differential Diagnosis of MDS, continued
- True or False: Vitamin B12 or folate deficiencies may cause megaloblastic changes in the bone marrow and peripheral blood cytopenia(s).
- True or False: Chemotherapeutic drugs cause bone marrow hyperplasia and leukocytosis.
- MDS Therapy
- MDS Therapy
- True or False: There are no FDA-approved drugs for the treatment of MDS.
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, medical laboratory technicians, laboratory supervisors, and laboratory managers. This course is also appropriate for MLS and MLT students and pathology residents.
Author Information: George Girgis, MLS(ASCP)CM, has over 30 years of experience as a medical laboratory scientist, during which time he has been a trainer and instructor at Indiana University Health in the fields of hematology and hematopathology. George holds a Bachelor of Medicine and a Bachelor of Surgery from Ein-Shams University, Cairo, Egypt, and a Bachelor of Science in Medical Laboratory Sciences from I.U.P.U.I., Indianapolis, IN.
Reviewer Information:
Joshua J. Cannon, MS, MLS(ASCP)CMSHCM, received his Bachelor
of Science and Master of Science in Medical Laboratory Science from Thomas
Jefferson University in Philadelphia, PA. He holds Medical Laboratory Scientist
and Specialist in Hematology certifications through the ASCP Board of
Certification. He was a professor at Thomas Jefferson University for seven
years before transitioning into his current role as Education Developer at
MediaLab. His areas of expertise and professional passions include clinical
hematology and interprofessional education.
Margaret Reinhart, MS, MLS(ASCP), is the MLS Program Director and Senior Lecturer in Biological Sciences at the University of the Sciences in Philadelphia, PA, where she teaches hematology, clinical immunology, parasitology, and other related courses. She is also an adjunct instructor in hematology at Pennsylvania Hospital, Philadelphia, PA. She holds a master's degree in biology and in health care administration.
