Course Outline
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- Introduction to the Macrocytic Anemias and Differentiating the Two Major Groups
- The Etiology of Megaloblastic Anemia
- Etiology of Non-Megaloblastic Macrocytic Anemia
- Causes of Non-Megaloblastic Macrocytic Anemia
- Alcoholism
- Drugs
- Myelodysplastic Syndrome (MDS)
- A patient has a slightly increased mean cell volume (MCV), along with an elevated red cell distribution width (RDW). Based on this information alone, ...
- Which of the following are known to cause non-megaloblastic macrocytic anemia?
- Laboratory Diagnosis of Megaloblastic Macrocytic Anemia
- Clinical Symptoms and Treatments for Macrocytic Anemia
- Case Study
- Case of a 49-Year-Old Patient
- Based on the CBC results below, how should the anemia be classified?ParameterResultHemoglobin 6.3 g/dLHematocrit 22%WBC 4 x 109/LMCV 128.6 fLMCH 36 p...
- What in the patient's history is suggestive of a B12 deficiency?
- Which of the following tests would not help differentiate between megaloblastic anemia caused by a B12 deficiency and one caused by folate deficiency?
- If the patient was diagnosed with a B12 deficiency, which further tests if any, would you do to follow up?
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists and medical laboratory technicians. This course is also appropriate for medical laboratory science students and pathology residents, as well as other interested healthcare providers.
Author Information: Margaret Reinhart MS, MT(ASCP), is a senior lecturer at the University of the Sciences where she has taught hematology since 1990. She was also director of the Medical Laboratory Science Program from 1990-2020. In addition, she is an adjunct instructor of Hematology at the Pennsylvania Hospital Medical Laboratory Science program, which is part of the Hospital of the University of Pennsylvania.
Reviewer Information: Laurie Bjerklie, MA, MLS(ASCP)CM is
currently an Education Developer for MediaLab and LabCE. She earned a B.S. in
Medical Laboratory Science from the University of North Dakota and an M.A. in
Curriculum and Instruction from Saint Xavier University. She has over 15 years
of experience in higher education and has held program director and faculty
positions in both MLT and MLS programs. She most recently served as the Program
Manager of Medical Laboratory Science at Saint Louis University.
Course Description: This course provides an overview of macrocytic anemias. Emphasis is placed on the differential diagnosis of the megaloblastic versus the non-megaloblastic macrocytic anemias. Information is also provided on the pathophysiological processes of each as well as mention of some treatment options.
