Breast Cancer Predictive Markers (Online CE Course)

(based on 114 customer ratings)

Author: Joelle Weaver MAOM, HTL(ASCP), QIHC
Reviewer: Carla Shoffeitt, MSM, HT(ASCP)

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Toxicity, side effects, and unpredictable effectiveness have been the hallmark of anti-cancer therapies used in the past to treat breast and other primary cancers. Targeted therapies have been developed which reduce patient risk and provide remarkable improvement in patient outcomes. This course will discuss how predictive markers/testing are used to select patients who are most likely to respond positively to a specific breast cancer treatment, including current testing methodologies and compliance standards.

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Continuing Education Credits

P.A.C.E.® Contact Hours (acceptable for AMT, ASCP, and state recertification): 1.5 hour(s)
Approved through 12/31/2022
Approved through 9/1/2022

Objectives

  • Recognize the value of predictive test results to clinical treatment decisions in human breast cancer.
  • Identify the main types of predictive testing performed in the histology laboratory.
  • Determine test methodologies used to identify the expression and amplification of human epidermal growth factor receptor 2 (HER2).
  • Examine current test methodologies used to identify the expression and amplification of HER2.
  • Identify compliance standards for validation, correlation, and proficiency testing under the guidelines set by the College of American Pathologists (CAP).

Customer Ratings

(based on 114 customer ratings)

Course Outline

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Additional Information

Level of instruction: Intermediate

Intended audience: This course is intended for histology bench technicians and technologists, supervisors, and administrators.

Author information: Joelle Weaver MAOM, HTL(ASCP), QIHC is a certified histotechnologist with a broad range of practical histology experience within the clinical histopathology setting. She has received qualification in immunohistochemistry (IHC) from the American Society for Clinical Pathology and Green Belt certification from Purdue University, West Lafayette, Indiana. Joelle's bachelor's degree was received from Bowling Green State University in Bowling Green, Ohio and her Master's Degree was awarded from Bluffton University in Bluffton, Ohio. She is a graduate of a NAACLS accredited histotechnology program and has held positions as adjunct professor, education coordinator, and program director at Columbus State Community College in Columbus Ohio (2002-2011). Joelle currently works as a histotechnologist and technical consultant in Louisville, Kentucky, specializing in IHC.

Reviewer information: Carla J. Shoffeitt, MSM, HT(ASCP) is the Manager of the Pathology Department of Emory St. Joseph’s Hospital of Emory Healthcare in Atlanta, Georgia. She holds a Master of Science Degree in Healthcare Management as well as a Bachelor of Science degree in Biology from Troy University, Troy, Alabama. She is certified as a Histotechnician and has 25 years of experience in the field of Histology.

Course description: Toxicity, side effects, and unpredictable effectiveness have been the hallmark of anti-cancer therapies used in the past to treat breast and other primary cancers. Targeted therapies have been developed which reduce patient risk and provide remarkable improvement in patient outcomes. This course will discuss how predictive markers/testing are used to select patients who are most likely to respond positively to a specific breast cancer treatment, including current testing methodologies and compliance standards.

Need multiple seats for your university or lab? Get a quote
Female white tech uses microscope (computer in background)


Metastatic breast cancer


HER2/<i>neu</i> gene FISH


3+ HER2 breast cancer detected with the Dako HercepTest. Image courtesy of Jim Burchette.


Adenovirus infected liver demonstrated with mouse IgG1 monoclonal antibody cocktail of clones 2/6 and 20/11. DAB chromogen.


DAB (brown) chromogen localized to cell membrane in HER2 stain using clone CB11. Counterstain is hematoxylin.