Course Outline
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- Introduction
- Course Introduction
- Antibody Detection and Identification
- Methods Used for Antibody Detection and Identification
- Antibody Detection and Identification
- Initial Steps for Identifying an Antibody
- Initial Observations of Antibody Panel
- Rule-Out Procedures
- Rule-Out Procedures, continued
- Ruling Out Example
- Ruling Out Example, continued
- Ruling Out Example, continued
- Case Study: Immune Alloantibody
- Case Study: Immune Alloantibody, continued
- Case Study: Immune Alloantibody, continuedUsing the information from the case study on the previous two pages, what antibody matches the pattern of re...
- Rule Out Procedures: Selecting Additional Rule-Out Cells
- Example of Selecting Additional Rule-Out Cells
- Based on initial serologic testing, a patient is suspected to have an anti-K, but anti-E cannot be ruled out. In this case, which of the following is ...
- Picking Selected Panel Cells Conservatively
- Rule-Out Procedure Summary Guidelines
- These antibody panel results were obtained on a patient sample. Which of the following antibodies could account for all of the reactions?Rh-HrKellDuff...
- Differentiate Between Naturally Occurring and Immune Antibodies
- Advanced Antibody Identification
- When to Suspect Multiple Antibodies
- Example of Dosage and/or Multiple Antibodies Influencing the Strength of Reactions
- Example of Multiple Antibodies
- Example of Multiple Antibodies, continued: Selected Cell Rule-Out Panel
- Example of Multiple Antibodies, continued: Explanation of Varying Strengths of Reactions
- When to Suspect an Autoantibody
- Cold Antibodies
- Example of Cold Autoantibody
- Example of Warm Autoantibody
- Is It a Cold or a Warm Autoantibody?
- What is an advanced technique that can help to determine the identity of other clinically significant antibodies that are present if a patient has an ...
- Antibodies to High Prevalence and Low Prevalence Antigens
- Conclusion
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Medical laboratory scientists, technicians, and pathologists. This course is also appropriate for medical laboratory science students and pathology residents.
Author Information: Margaret Alba, DOM, CLS(NCA), BB(ASCP) is a Lecturer in Clinical Immunohematology at the University of New Mexico in Albuquerque, New Mexico, and a Medical Technologist at Tricore-University Hospital, also located in Albuquerque. She holds a Master's in Oriental Medicine from the International Institute of Chinese Medicine and a Bachelor of Science degree in Medical Technology from the University of Texas at El Paso.
Reviewer Information: Chelsey Geurkink, MS, MLS(ASCP)CMSBBCM, is an instructor for the Specialist in Blood Banking and Medical Laboratory Science program within the College of Health Sciences at RUSH University. She completed her Bachelor of Science at the University of Wisconsin-Madison in Biology and Bachelor of Science in Medical Laboratory Science at RUSH University. She completed her graduate degree in Clinical Laboratory Management at RUSH University. Chelsey received the Teaching Assistant of the Year award in the Medical Laboratory Science Department at RUSH University in 2015 and was recognized for her accomplishment in education and training in the field of transfusion medicine by the American Association of Blood Banks in 2019. She is currently the Manager of RUSH University Medical Center's Blood Bank.
Course Description: This course will take you through methods that can be used in the process of identifying an antibody in transfusion medicine. Many examples are presented that take you step-by-step through these procedures and provide you with appropriate panel results.
