Course Outline
Click on the links below to preview selected pages from this course.
- Alzheimer's Disease (AD): Overview
- Definition, Facts, and Statistics
- Signs, Symptoms, and Stages
- Causes, Risk Factors, and Prevention
- Causes, Risk Factors, and Prevention (Continued)
- Which of the following statements correctly describes Alzheimer’s Disease (AD)?
- Which “stage” of Alzheimer’s Disease (AD) is typically the longest (often lasting for many years), with the individual having diffic...
- Alzheimer’s Disease (AD) is believed to be caused by a combination of genetic, lifestyle, and environmental factors.
- Diagnosis of Alzheimer’s Disease (AD):
- Overview and Diagnostic Approaches
- Overview and Diagnostic Approaches (Continued)
- Which statements are correct regarding the diagnosis of AD?
- Which specific type of PET scan measures the neurofibrillary tangles in the brain?
- Genetic testing of certain genes involved in the development of AD is available, and the use of such genetic testing for routine AD evaluation is now ...
- Genetics of AD
- Risk Genes and Deterministic Genes
- Risk Genes and Deterministic Genes (Continued)
- Summary on Genetic Testing for AD
- In a small percentage of AD cases, genetic mutations occurring in certain genes can directly cause AD. What is the name given to these genes?
- Alzheimer's Disease (AD) Biomarkers
- AD Biomarkers: Overview
- AD Biomarkers: Key Biomarkers
- AD Biomarkers: Key Biomarkers (Continued)
- AD Biomarkers: Key Biomarkers (Continued)
- AD Biomarkers: Key Biomarkers (Continued)
- AD Biomarkers: Key Biomarkers (Continued)
- CSF or Blood Biomarkers for AD?
- Which statements are true relative to biomarkers for AD?
- Which peptide, when deposited in plaques, can be found in low levels in the CSF and may be a key biomarker of AD?
- A blood assay to detect IRS-1 protein has been developed and studied. Studies have shown that individuals with AD may have lower blood levels of the i...
- What is the p-tau217 biomarker, and what does the latest research indicate?
- What are the limitations to the use of CSF for measuring biomarkers of AD?
- Commercially-available Biomarker Tests for AD Assessment
- Introduction to Commercially-available Tests for AD Assessment
- Quest Diagnostic’s Beta-Amyloid 42/40 Ratio and Apolipoprotein E (APOE) Isoform Panel:
- LabCorp’s APOE Alzheimer’s Risk Test:
- Athena Diagnostic’s ADmark Alzheimer’s Evaluation
- The C2N Diagnostics (C2N) PrecivityAD Test
- The C2N Diagnostic's Precivity AD2 Blood Test (update)
- FDA "Breakthrough Device" Approvals for AD Diagnostic Tests
- FDA "Breakthrough Device" Approvals for AD Diagnostic Tests (Continued)
- Which of the following are true statements when describing Quest Diagnostic’s AB42/40 ratio and APOE isoform Panel test?
- One limitation of using LabCorp’s APOE Alzheimer’s Risk Test is that the presence of the APOE e4 isoform does increase the risk of late-on...
- The Athena Diagnostic’s ADmark Alzheimer’s Evaluation test measures which AD biomarkers?
- Which of the following describes the C2N PrecivityAD test?
- Which of the following commercial diagnostic tests have been given FDA “Breakthrough Device” approval for the measurement of AD biomarkers...
- Conclusions on Biomarker Tests for AD Assessment
- Treatment of Alzheimer's Disease (AD)
- Treatment Overview
- Alzheimer's Drugs
- Alzheimer's Drugs (Continued)
- Alzheimer's Drugs (New FDA Drug)
- Other Treatments
- Which statements are true relative to the treatment of AD?
- One of the types of current AD medications are Cholinesterase Inhibitors. These medications slow the progression of symptoms associated with moderate ...
- Which statements are correct when describing the drug Aduhelm?
- References
Additional Information
Level of Instruction: Intermediate
Intended Audience: Clinical laboratory professionals including medical laboratory scientists, medical technologists, and technicians. This course is also appropriate for clinical laboratory science and MLT students, pathologists, and clinicians.
Author Information: David J. Moffa, PhD, BCLD, has over 30 years of experience in the healthcare industry as an executive manager, clinical laboratory director, and medical laboratory scientist. He is currently a technical consultant for Kentmere Healthcare, Wilmington, DE, and until his retirement, was the Regional Director for LabCorp, Inc. He holds a PhD in medical biochemistry from the School of Medicine, West Virginia University.
Reviewer Information:
Kevin F. Foley, PhD, DABCC, MT, SC is the director of clinical pathology for the Kaiser Permanente Northwest region. He also teaches clinical chemistry at Oregon Health Sciences University. Dr. Foley earned his PhD in clinical pharmacology and toxicology at East Carolina School of Medicine in North Carolina.
Prior to her retirement in 2012, Jenny Camele was employed by Laboratory Corporation of America as the manager of customer service operations for the Fairmont West Virginia Region and a Quality Assurance committee member. She holds a Bachelor of Science degree in Medical Technology from West Virginia University.
