FAB Classification

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The page below is a sample from the LabCE course Acute Leukemia with a Focus on WHO Classification. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Acute Leukemia with a Focus on WHO Classification (online CE course)
FAB Classification

In the former FAB classification, ALL was divided into three types based on cell size, prominence of nucleoli, and amount and appearance of cytoplasm:
  • L1 (found mostly in children)
  • L2 (found mostly in older children and adults)
  • L3 (associated with Burkitt's Lymphoma)
The image to the right is a smear from a bone marrow that was diagnosed as ALL L1, often seen in children. Notice the consistently sized lymphoblasts with scant cytoplasm.
11. Hanggara, Dian Sukma. "Leukemia Limfoblastik Akut L1 (ALL-L1)." PatologiKlinik.com, 4 Aug 2017, https://patologiklinik.com/2017/08/04/leukemia-limfoblastik-akut-l1-all-l1/

A smear from a bone marrow that was diagnosed as ALL L1 (11).