Prognosis of AML

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The page below is a sample from the LabCE course Acute Leukemia with a Focus on WHO Classification. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Prognosis of AML

As stated earlier, accurate diagnosis of the specific WHO subtype will help to determine the patient's prognosis, their response to therapy, their likelihood of remission, and their overall chances of survival.
According the Merck Manual Professional Edition (2018), Table 9 provides some examples of different WHO subtypes and their prognoses.
Table 9. WHO Subtypes and their Prognoses of AML.
PrognosisCytogenetic Abnormality/Mutation
Favorablet(15;17)(q24.1q24.1)/PML-RARA
t(8;21)/(q22q22.1)/RUNX1-RUMX1T1
AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB- MYH11
IntermediateNormal karyotype
PoorTrisomy 8