The WHO classification of AML includes many more individual diagnostic categories than the old FAB list of M0-M7.
The major categories of AML are:
- AML with recurrent genetic abnormalities
- AML with myelodysplasia-related changes
- AML not otherwise specificied (NOS)- (several of the subcategories of this group are on the FAB M0-M7 list)
- Myeloid sarcoma
- Myeloid proliferation related to Down Syndrome
Table 5 gives a complete list of the subcategories of each category. This is for your reference, and it is beyond the scope of this course to cover each. A few of the more common ones will be mentioned in subsequent pages.
Table 5. Complete WHO AML Classification.AML Category | Subcategories |
AML with recurrent genetic abnormalities | AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1 AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFβ- MYH11 APL with PML-RARA AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A AML with t(6;9)(p23;q34.1);DEK-NUP214 AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1 Provisional entity: AML with BCR-ABL1 AML with mutated NPM1 AML with biallelic mutations of CEBPA Provisional entity: AML with mutated RUNX1 |
AML with myelodysplasia-related changes | |
Therapy-related myeloid neoplasms | |
AML NOS (not otherwise specified) | AML with minimal differentiation AML without maturation AML with maturation Acute myelomonocytic leukemia Acute monoblastic/monocytic leukemia Pure erythroid leukemia Acute megakaryoblastic leukemia Acute basophilic leukemia Acute panmyelosis with myelofibrosis |
Myeloid sarcoma | |
Myeloid proliferations related to Down Syndrome | Transient abnormal myelopoiesis (TAM) Myeloid leukemia associated with Down Syndrome |