Complete WHO AML Classification

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The page below is a sample from the LabCE course Acute Leukemia with a Focus on WHO Classification. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

Learn more about Acute Leukemia with a Focus on WHO Classification (online CE course)
Complete WHO AML Classification

The WHO classification of AML includes many more individual diagnostic categories than the old FAB list of M0-M7.
The major categories of AML are:
  • AML with recurrent genetic abnormalities
  • AML with myelodysplasia-related changes
  • AML not otherwise specificied (NOS)- (several of the subcategories of this group are on the FAB M0-M7 list)
  • Myeloid sarcoma
  • Myeloid proliferation related to Down Syndrome
Table 5 gives a complete list of the subcategories of each category. This is for your reference, and it is beyond the scope of this course to cover each. A few of the more common ones will be mentioned in subsequent pages.
Table 5. Complete WHO AML Classification.
AML CategorySubcategories
AML with recurrent genetic abnormalities AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFβ- MYH11
APL with PML-RARA
AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
AML with t(6;9)(p23;q34.1);DEK-NUP214
AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
Provisional entity: AML with BCR-ABL1
AML with mutated NPM1
AML with biallelic mutations of CEBPA
Provisional entity: AML with mutated RUNX1
AML with myelodysplasia-related changes
Therapy-related myeloid neoplasms
AML NOS (not otherwise specified) AML with minimal differentiation
AML without maturation
AML with maturation
Acute myelomonocytic leukemia
Acute monoblastic/monocytic leukemia
Pure erythroid leukemia
Acute megakaryoblastic leukemia
Acute basophilic leukemia
Acute panmyelosis with myelofibrosis
Myeloid sarcoma
Myeloid proliferations related to Down SyndromeTransient abnormal myelopoiesis (TAM)
Myeloid leukemia associated with Down Syndrome