Secondary Hemostasis – The Common Pathway

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The page below is a sample from the LabCE course Fundamentals of Hemostasis. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online.

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Secondary Hemostasis – The Common Pathway

Thrombin, after its conversion from prothrombin, catalyzes the conversion of fibrinogen into a fibrin monomer. Additionally, thrombin triggers the conversion of factor XIII into factor XIIIa which forms covalent bonds that crosslink and stabilize the fibrin monomers.

Finally, thrombin feeds back into the intrinsic and common pathways, accelerating the action of factors XI, V, and VIII. As large quantities of thrombin accumulate, it begins to have a down-regulating function by inhibiting several coagulation factors and thus slowing down the cascade.