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Heparin vs Warfarin Summary Chart
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Heparin vs Warfarin Summary Chart
Heparin
Warfarin
How fast does it work?
Within minutes
Days later
How is it given?
Injected
By mouth
Where does it work?
In the blood
In the liver
How does it work?
Enhances ATIII activity, increases inhibition of thrombin (factor IIa)
Prevents Vitamin K from modifying factors II, VII, IX, and X to their active form
Lab monitoring?
aPTT, with goal aPTT 1.5 - 2.5X reference range
INR with goal INR of 2-3
Antidote in toxicity?
Protamine
Vitamin K
How long is it used?
For a shorter period of time
Long term
Safe in pregnancy?
Yes
No
X
×